Related Experiment Video
Updated: May 23, 2025

08:47
Evaluation of Cardiac Contractility Modulation Therapy in 2D Human Stem Cell-Derived Cardiomyocytes
Published on: December 16, 2022
2.3K
Cardiac Contractility Modulation Therapy and Device Algorithm-related Challenges
Farman Ali1, Khurram Arshad1, Rabia Latif2
1Department of Cardiology, Corewell Health Dearborn Hospital, Dearborn, MI, USA.
The Journal of Innovations in Cardiac Rhythm Management
|March 7, 2025
Summary
Cardiac contractility modulation (CCM) offers a promising treatment for heart failure with reduced ejection fraction (HFrEF). This article emphasizes the need for provider training and a troubleshooting algorithm to optimize CCM device management for better patient outcomes.
Area of Science:
- Cardiology
- Biomedical Engineering
Background:
- Heart failure (HF) is a critical condition with high morbidity, mortality, and reduced quality of life.
- HF with reduced ejection fraction (HFrEF) significantly impacts patients' functional capacity and healthcare costs.
- Cardiac contractility modulation (CCM) is an emerging device-based therapy for HFrEF.
Related Concept Videos
Pathophysiology of Cardiac Performance
499
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
499
Heart Failure Drugs: Inotropic Agents
488
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
488

