Related Experiment Video
Updated: May 23, 2025

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Enhancing diabetes therapy with pH-sensitive co-delivery of metformin hydrochloride and glipizide using MCM-48-based
Debatrayee Dasgupta1, Anjali Patel1
1Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda Vadodara 390002 India anjali.patel-chem@msubaroda.ac.in.
Abstract:
Monotherapy in diabetes management is losing interest due to its ineffectiveness in achieving optimal glycaemic control in a significant proportion of diabetic patients. Therefore, combined therapy is increasingly preferred by clinicians, which offers enhanced effectiveness and a better safety profile for managing the condition. The present work deals with the designing of a dual drug nanocarrier based on MCM-48 and 12-tungtophosphoric acid (TPA) for the co-delivery of Glipizide (GLP) and Metformin Hydrochloride (MTF) as well as its characterization using various techniques. An in vitro release study was carried out at two different pHs (pH 1.2 and pH 7.4) at 37 °C under stirring conditions which was further supported by an in vitro dissolution study carried out using a USP Type II dissolution apparatus. The obtained results were compared with that of the marketed available formulation, Glirum-MF, and the designed nanocarrier showed a better controlled release of both the drugs in comparison with the conventional drug. Additionally, considering the anticancer properties of both the drugs, MTT assay indicated that the carrier is non-toxic while the drug loaded nanocarrier shows apoptosis against HepG2 cells.
More Related Videos
09:31Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
Published on: November 5, 2016
06:34Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
Published on: November 29, 2024
Related Concept Videos
Oral Hypoglycemic Agents: Biguanides and Glitazones
Oral Hypoglycemic Agents: Glinides
Dipeptidyl Peptidase 4 Inhibitors
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into...
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...