Related Experiment Video

Updated: May 23, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.6K

Notch signaling in cancers: mechanism and potential therapy

Chen Chen1, Yan Du2, Rongzu Nie1

  • 1College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.

Frontiers in Cell and Developmental Biology
|March 7, 2025
PubMed

Insights

The Notch signaling pathway regulates cell functions and is crucial in cancer. This review examines Notch

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • The Notch signaling pathway is a conserved intercellular cascade regulating cell development, proliferation, apoptosis, and genome stability.
  • Its pervasive role in the human body significantly impacts tumorigenesis and cancer progression.
  • Aberrant Notch signaling is implicated in various malignant tumors.

Purpose of the Study:

  • To review the mechanism of Notch signaling in lung, liver, and colorectal cancer.
  • To explore future therapeutic strategies targeting the Notch signaling pathway for cancer treatment.

Main Methods:

  • Literature review of studies on Notch signaling in cancer.
  • Analysis of the role of Notch in specific cancer types (lung, liver, colorectal).

Main Results:

  • Notch signaling influences multiple cellular functions in tumor cells.
  • Aberrant Notch expression/mutation is linked to cancer onset and progression.
  • Detailed mechanisms of Notch signaling in lung, liver, and colorectal cancers were discussed.

Conclusions:

  • Modulating the Notch signaling pathway presents promising therapeutic avenues for cancer treatment.
  • Further research into Notch signaling mechanisms can lead to novel anti-cancer strategies.
Keywords:
cancermechanismmutationsnotch signalingpotential therapy

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