A review of AI-based radiogenomics in neurodegenerative disease

Neurodegenerative diseases are chronic, progressive conditions that cause irreversible damage to the nervous system, particularly in aging populations. Early diagnosis is a critical challenge, as these diseases often develop slowly and without clear symptoms until significant damage has occurred. Recent advances in radiomics and genomics have provided valuable insights into the mechanisms of these diseases by identifying specific imaging features and genomic patterns. Radiogenomics enhances diagnostic capabilities by linking genomics with imaging phenotypes, offering a more comprehensive understanding of disease progression. The growing field of artificial intelligence (AI), including machine learning and deep learning, opens new opportunities for improving the accuracy and timeliness of these diagnoses. This review examines the application of AI-based radiogenomics in neurodegenerative diseases, summarizing key model designs, performance metrics, publicly available data resources, significant findings, and future research directions. It provides a starting point and guidance for those seeking to explore this emerging area of study.