Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gestational lipid profile partially mediates adverse obstetric outcomes associated with polycystic ovary syndrome: a multicentre cohort study in China.

Lipids in health and disease·2026

Same author

DiRIC: Diffusion Prior Refinement for Efficient Low-rate Image Compression.

IEEE transactions on pattern analysis and machine intelligence·2026

Same author

Swine acute diarrhea syndrome coronavirus nsp5 induces apoptosis by targeting GATA zinc finger domain-containing protein 2A (GATAD2A/p66α).

mBio·2026

Same author

Mitochondrial transfer: A comprehensive analysis of mechanistic insights, preclinical applications, and technological innovations.

Neural regeneration research·2026

Same author

Tetramethylpyrazine promotes spinal cord injury repair by modulating macrophage M1/M2 polarization via inhibition of the IL-6/JAK2/STAT3 pathway.

Toxicology and applied pharmacology·2026

Same author

Research on multi modal corn seed vitality grading based on three branch cross attention fusion network.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026

Search research articles

Related Experiment Video

Updated: May 23, 2025

Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli

Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli

Published on: December 26, 2020

Cisplatin Promotes Hepatotoxicity by cGAS-STING Mediated Innate Immune Response.

Qiongyan Tao¹, Yimin Zhou¹, Genwen Chen²

¹Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.

Journal of Gastroenterology and Hepatology

|March 7, 2025

Summary

Cisplatin chemotherapy causes liver injury by activating the cGAS-STING-IFN-I pathway. Inhibiting this pathway protects against this damage, offering a new therapeutic target for chemotherapy side effects.

More Related Videos

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Published on: May 15, 2021

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

Related Experiment Videos

Last Updated: May 23, 2025

Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli

Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli

Published on: December 26, 2020

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Published on: May 15, 2021

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

Area of Science:

Hepatology
Immunology
Pharmacology

Background:

Platinum-based chemotherapy, like cisplatin, is crucial for cancer treatment but causes significant liver injury.
Current strategies to prevent or treat cisplatin-induced liver injury (CILI) are limited.
The type I interferon (IFN-I) pathway is implicated in CILI.

Purpose of the Study:

To investigate the role of the cGAS-STING signaling pathway in cisplatin-induced liver injury.
To identify potential therapeutic targets for mitigating CILI.

Main Methods:

RNA sequencing analysis in a CILI mouse model.
In vitro and in vivo studies assessing cGAS-STING pathway activation.
Experimental inhibition of the cGAS-STING pathway using dsDNA digestion or cGAS knockout.

Main Results:

Cisplatin treatment significantly upregulated the IFN-I pathway and activated cGAS-STING signaling in liver cells and in vivo.
Cisplatin-induced DNA damage triggers dsDNA release, activating the cGAS-STING pathway.
Activation of this axis promotes IFN-I production and apoptosis, leading to liver injury.
Inhibiting cGAS-STING signaling effectively reduced IFN-I production and liver injury.

Conclusions:

The cGAS-STING-IFN-I axis is a key mediator of cisplatin-induced liver injury.
Targeting the cGAS-STING pathway presents a promising strategy for preventing and treating platinum-based drug hepatotoxicity.