Risk Factors for Developing Advanced Chronic Kidney Disease in Pancreas Transplant Alone Recipients
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View abstract on PubMed
Summary
This summary is machine-generated.Pancreas transplant alone patients can develop advanced chronic kidney disease (CKD). Older recipient age and donor hypertension increase CKD risk, while higher BMI and pretransplant eGFR are protective factors.
Area Of Science
- Nephrology
- Transplantation Immunology
- Clinical Medicine
Background
- Pancreas transplant alone (PTA) recipients are at risk for developing advanced chronic kidney disease (CKD).
- Identifying pretransplant predictors of CKD progression is crucial for patient management.
Purpose Of The Study
- To identify pretransplant factors in PTA recipients that predict the progression to advanced CKD.
- To inform donor and recipient selection strategies to mitigate CKD risk.
Main Methods
- Retrospective analysis of primary PTA recipients with over 2 weeks of graft survival.
- Advanced CKD defined by need for dialysis, kidney transplant, eGFR <30 mL/min/1.73 m², or proteinuria.
- Utilized race-neutral NKF eGFR calculator for all calculations.
Main Results
- 13% (24/179) of PTA recipients developed advanced CKD.
- Lower pretransplant eGFR (<80 mL/min/1.73 m²) was associated with increased CKD risk (P=0.002).
- Older recipient age (HR 1.04) and donor hypertension (HR 2.63) increased advanced CKD risk; higher recipient BMI (HR 0.84) and pretransplant eGFR (HR 0.97) were protective.
Conclusions
- Pretransplant recipient age, donor hypertension, recipient BMI, and pretransplant eGFR are significant predictors of advanced CKD in PTA recipients.
- These factors can guide clinical decision-making in donor-recipient matching.
- Further research may refine risk stratification for CKD development post-pancreas transplantation.
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