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Methyltransferase-Like 3-Mediated N6-Methyladenosine Modification on RNAs: A Novel Perspective for the Pathogenesis

Dongqiong Xiao1, Deshuang Zhang1,2, Yi Qu1

  • 1Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

Journal of Cellular and Molecular Medicine
|March 7, 2025
PubMed

Insights

Methyltransferase-like 3 (METTL3) impacts gene expression in bone diseases like osteoarthritis and osteoporosis. This review highlights METTL3 as a potential diagnostic biomarker and therapeutic target for these prevalent conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Osteoarthritis, osteoporosis, and osteosarcoma are significant bone pathologies with high mortality and therapeutic resistance.
  • Aberrant chondrocyte, osteoclast, and osteoblast function underlies these prevalent osseous conditions.
  • Investigating novel mechanistic insights is crucial for mitigating these health threats.

Purpose of the Study:

  • To systematically review and summarize current research on the role of Methyltransferase-like 3 (METTL3) in bone pathologies.
  • To evaluate the clinical significance and implications of METTL3 in osteoarthritis, osteoporosis, and osteosarcoma.
  • To elucidate METTL3's function in mediating N6-methyladenosine (m6A) modifications and its impact on cellular processes in bone diseases.

Main Methods:

  • Systematic review and aggregation of contemporary studies.
  • Analysis of existing literature on METTL3's involvement in osteoarthritis, osteoporosis, and osteosarcoma.
  • Examination of METTL3's role in RNA m6A modifications and gene expression regulation.

Main Results:

  • METTL3 plays a pivotal role in the pathogenesis of osteoarthritis, osteoporosis, and osteosarcoma.
  • METTL3 mediates m6A modifications on both messenger RNAs (mRNAs) and non-coding RNAs, influencing cellular functions.
  • Evidence suggests METTL3 acts as a risk gene in these bone conditions.

Conclusions:

  • METTL3 is significantly correlated with osteoarthritis, osteoporosis, and osteosarcoma.
  • METTL3 holds potential as a critical diagnostic biomarker for these bone pathologies.
  • Targeting METTL3 may offer a novel therapeutic strategy for managing bone diseases.
Keywords:
RNA N6‐methyladenosine modificationdiagnosismethyltransferase‐like 3osteoarthritisosteoporosisosteosarcomatreatment

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