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Published on: May 5, 2022
Role and mechanism of seaweed polysaccharides in regulating mitochondrial dysfunction: A review
Lina Wu1, Dandan Huang2, Sitong Wang1
1College of Food Science, Southwest University, Chongqing, China.
Abstract:
Seaweed polysaccharides are naturally occurring macromolecules in seaweeds with a variety of health benefits. Their multiple health benefits are attributed to their regulatory effects on mitochondrial function. However, the relationship between the source of seaweed polysaccharides, polysaccharide properties, and mitochondrial dysfunction has not been comprehensively reviewed. This review summarizes the sources of seaweed polysaccharides, effects of polysaccharide properties (including molecular weight, monosaccharide composition, chemical structure, and functional groups) on regulating mitochondrial function, as well as their main potential regulatory mechanisms (including mitochondrial respiratory chain, mitochondrial membrane structural integrity, mitochondrial DNA, mitochondrial dynamic, mitochondrial autophagy, and mitochondrial Ca2+ homeostasis), with the aim to provide a theoretical reference to promote further research on the development and application of seaweed polysaccharides.
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