Related Experiment Video
Updated: May 23, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Azacitidine-induced bullous pemphigoid-like localized toxic reaction
Rodrigo Brêtas Emerich Nogueira1, Nelson Hidekazu Tatsui1, Laura Ramos de Almeida2
1Department of Hematology, Hemotherapy and Cell Therapy, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Abstract:
Azacitidine is a hypomethylating agent recommended for the treatment of patients with high-risk myelodysplastic syndromes. Here, we report the case of a patient with myelodysplastic syndrome who was not eligible for allogeneic stem cell transplantation (allo-SCT) and presented with a rare and previously unreported cutaneous side effect after the use of subcutaneous azacitidine. We propose that changing the route of azacitidine administration from subcutaneous to intravenous could potentially decrease the occurrence of bullous pemphigoid-like localized toxic reactions in some patients.
More Related Videos
Related Concept Videos
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Allergic Drug Reactions
Allergic Reactions
Drugs for Treatment of Ulcerative Colitis in IBD
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Phase II Reactions: Acetylation Reactions
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...

