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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
Dead-End protein expression, function, and mutation in cancer: a systematic review
Homa Faraji1,2, Farnaz Banakar3, Arash Sadri2,4
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Molecular Biology Reports
|March 7, 2025
Summary
Dead-end protein 1 (DND1) has dual roles in cancer, acting as both a tumor suppressor and promoter. Understanding DND1
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Global cancer incidence is increasing, especially in aging populations.
- Understanding cancer's genetic and molecular mechanisms is vital for effective interventions.
- Dead-end protein 1 (DND1) is an RNA-binding protein critical in germ cell regulation and tumorigenesis.
Purpose of the Study:
- To systematically review DND1's roles in cancer progression.
- To evaluate DND1's interactions and therapeutic potential.
- To elucidate DND1's molecular mechanisms in cancer.
Main Methods:
- Systematic literature search across four major databases (Web of Science, PubMed, Scopus, Embase).
- Screening of 436 unique records, with 38 studies included for data extraction.
- STRING-based network analysis to identify DND1 interactors and associated pathways.
Main Results:
- DND1 exhibits context-dependent dual roles: tumor suppressor and tumor promoter.
- Key DND1 interactors include NANOS1-3, TDRD7, DAZL, and EIF2S2.
- Identified pathways involve RNA binding, translational regulation, and apoptosis.
- DND1's regulation of microRNAs (miRNAs) and germ cell proteins are critical mechanisms.
Conclusions:
- DND1 plays a central role in cancer biology with diagnostic and therapeutic implications.
- Findings support experimental validation of DND1 interactions and mechanisms.
- DND1's dual function offers potential for novel cancer therapies, especially for germ cell tumors.
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