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Published on: June 4, 2012
Streptococcus suis endocarditis: prognostic factors and antimicrobial resistance
Wilawan Thipmontree1, Udomsak Lerssuttipon2, Piyapat Chunharas2
1Division of Infectious Diseases, Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima, Thailand.
Streptococcus suis causes infective endocarditis (IE) in 51% of bacteremia cases, especially with penicillin-resistant strains. Managing these drug-resistant infections is crucial due to high mortality rates.
Area of Science:
- Infectious Diseases
- Cardiology
- Microbiology
Background:
- Streptococcus suis is a significant zoonotic pathogen globally.
- Infective endocarditis (IE) is a severe complication of S. suis bacteremia.
Purpose of the Study:
- Identify prognostic factors for IE development in S. suis bacteremia.
- Determine factors associated with mortality in these patients.
Main Methods:
- Retrospective cross-sectional study of patients with S. suis infection (2021-2023).
- Reviewed medical records and echocardiogram results.
- Multivariable analysis to identify risk factors.
Main Results:
- 51% of S. suis bacteremia patients developed IE.
- Penicillin-resistant strains (aPR: 7.94) and persistent bacteremia (aPR: 1.58) increased IE risk.
- Mortality was higher in IE patients (28.4%) vs. non-IE (15.3%).
- Embolic stroke and acute kidney injury significantly increased mortality risk.
Conclusions:
- S. suis is a frequent cause of IE, particularly with resistant strains.
- Echocardiography is recommended for S. suis bacteremia.
- Managing drug-resistant S. suis infections poses a significant challenge.
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