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Multifunctional Chitosan/Cellulose/Tannic Acid Biocomposite Sponge with Excellent Biocompatibility for Rapid
Yuanyuan Ma1, Guowei Da1, Lei He1,2,3
1College of Materials Science and Engineering, Nanjing Forestry University (NFU), Nanjing 210037, China.
Biomacromolecules
|March 7, 2025
Summary
New chitosan/cellulose/tannic acid (CS/OMCC/TA) biocomposite sponges offer rapid and efficient hemostasis. These biocompatible materials show excellent absorption, antioxidant, and antibacterial properties for trauma and surgical applications.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Biomedical Engineering
Background:
- Hemostatic materials require efficient hemostasis, biocompatibility, and non-toxicity.
- Conventional hemostatic sponges often exhibit poor mechanical strength, low biocompatibility, and slow hemostasis.
Purpose of the Study:
- To develop novel, multifunctional chitosan/cellulose/tannic acid (CS/OMCC/TA) biocomposite sponges.
- To evaluate the hemostatic, absorption, antioxidant, and antibacterial properties of the developed sponges.
Main Methods:
- Fabrication of CS/OMCC/TA biocomposite sponges using a freeze-drying method without chemical cross-linking agents.
- Assessment of water and blood absorption rates.
- In vitro coagulation tests.
- DPPH radical scavenging assays and antibacterial experiments.
- In vivo animal studies for hemostasis evaluation.
Main Results:
- The CS/OMCC/TA biocomposite sponges exhibited high water (4404%) and blood (5460%) absorption rates.
- In vitro tests demonstrated superior coagulation ability compared to commercial hemostatic materials.
- Excellent antioxidant properties and significant inhibition against Staphylococcus aureus and Escherichia coli were observed.
- Animal experiments showed rapid hemostasis within 185 seconds with minimal blood loss (107 mg).
Conclusions:
- The developed CS/OMCC/TA biocomposite sponges are effective, biocompatible, and rapid hemostatic agents.
- These novel sponges show potential for emergency trauma treatment and surgical hemostasis.
- The study highlights the advantages of freeze-dried chitosan-based composites in hemostatic applications.
