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Updated: May 23, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Published on: July 17, 2019

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Condensates as a Culprit in RAS Activation and Inhibitor Resistance.

Hannah C Bergo1,2,3, Logan B Leak1,2,3, Trever G Bivona1,2,3,4

  • 1Department of Medicine, University of California, San Francisco, San Francisco, California.

Cancer Research
|March 7, 2025
PubMed
Summary

ARAF protein forms novel condensates that sustain RAS signaling, driving therapy resistance in cancers. Targeting these ARAF-RAS condensates may overcome resistance to RAS-targeted treatments.

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