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Hypnotic drug use and intraoperative fluid balance associated with postoperative delirium following pancreatic

Zhi-Hua Huang1, Jun Zhang2, Xiao-Ying Xu1

  • 1Department of Anesthesiology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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|March 7, 2025
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Summary
This summary is machine-generated.

Postoperative delirium after pancreatic surgery is linked to older age, hypnotic drug use, and high intraoperative fluid balance. Identifying these risk factors can help prevent delirium in surgical patients.

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Area of Science:

  • Medical research
  • Surgical outcomes
  • Neuroscience

Background:

  • Postoperative delirium is a frequent complication following major surgical procedures.
  • Pancreatic surgery carries a significant risk for developing this cognitive impairment.
  • Identifying specific risk factors is crucial for patient management.

Purpose of the Study:

  • To determine the key risk factors associated with the development of delirium after pancreatic surgery.
  • To provide data for targeted interventions to reduce delirium incidence.

Main Methods:

  • Retrospective analysis of patient data from Ruijin Hospital (July 2020 - March 2021).
  • Inclusion of patients who underwent pancreatic surgery.
  • Statistical analysis using univariate and multivariate Logistic regression.

Main Results:

  • 15.3% of patients (59 out of 385) developed postoperative delirium.
  • Independent risk factors identified: age ≥ 65 years, hypnotic drug use, and intraoperative fluid balance (>2863ml).
  • Age (OR 2.01), hypnotic drug use (OR 4.17), and fluid balance (OR 2.57) were statistically significant predictors.

Conclusions:

  • Intraoperative fluid balance and hypnotic drug use are significant independent risk factors for postoperative delirium post-pancreatic surgery.
  • Age is also a critical factor contributing to delirium risk.
  • These findings highlight modifiable and non-modifiable factors for delirium prevention strategies.