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Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

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Web-Based Application for Reducing Methamphetamine Use Among Aboriginal and Torres Strait Islander People: Randomized

Rachel Reilly1,2, Rebecca McKetin3, Federica Barzi4

  • 1Wardliparingga Aboriginal Health Equity, South Australian Health and Medical Research Institute, Adelaide, Australia.

Journal of Medical Internet Research
|March 7, 2025
PubMed
Summary
This summary is machine-generated.

This study found that the "We Can Do This" web app did not significantly reduce methamphetamine use or improve well-being in Aboriginal and Torres Strait Islander people due to poor engagement and low adherence.

Keywords:
Aboriginal and Torres Strait Islander Healthappdigital interventionseffectivenessmethamphetaminemethamphetamine usemobile phonepsychosocial distresspsychosocial wellbeingrandomised controlled trialsubstance usetherapeutic programtreatmentweb-based intervention

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Area of Science:

  • Digital health interventions
  • Substance use treatment
  • Indigenous health

Background:

  • Digital interventions can overcome barriers to care for Aboriginal and Torres Strait Islander people.
  • The "We Can Do This" app was developed to support methamphetamine cessation and improve well-being.
  • Culturally appropriate digital tools are needed to address substance use challenges.

Purpose of the Study:

  • To evaluate the effectiveness of the "We Can Do This" web app.
  • To assess its impact on methamphetamine use and psychosocial well-being.
  • To determine its viability as a treatment for Aboriginal and Torres Strait Islander people.

Main Methods:

  • A randomized waitlist controlled trial was conducted.
  • Participants were Aboriginal and Torres Strait Islander people using methamphetamine weekly.
  • The study assessed methamphetamine use, dependence, distress, and help-seeking behavior over 3 months.

Main Results:

  • No significant differences were found in methamphetamine use or psychosocial outcomes between the app group and the waitlist control.
  • Participant adherence to the web app was poor, with only 20% returning after initial login.
  • Low follow-up rates (54-63%) limited the evaluation's power.

Conclusions:

  • The
  • We Can Do This
  • web app showed poor engagement and no significant effect on methamphetamine use or well-being.
  • Low adherence and follow-up rates hindered the assessment of the app's effectiveness.
  • Future digital interventions must prioritize strategies to enhance participant engagement and retention for this population.