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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
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CAR T-cell therapy chest CT manifestations
Dorine de Jong1, Saheeb Ahmed2, Belinda Dsouza3
1RefleXion Medical Inc., Hayward, CA, USA.
Clinical Imaging
|March 7, 2025
Summary
Pleural effusion is the most frequent chest CT finding after CAR T-cell therapy. New patient symptoms like cough or dyspnea may indicate these radiologic abnormalities, warranting clinical attention.
Area of Science:
- Oncology
- Radiology
- Immunotherapy
Background:
- Chimeric antigen receptor (CAR) T-cell therapy is a novel immunotherapy for cancer treatment.
- Assessing the radiological impact of CAR T-cell therapy is crucial for patient management.
Purpose of the Study:
- To identify and characterize the most common chest computed tomography (CT) findings in patients receiving CAR T-cell therapy.
- To correlate CT manifestations with clinical symptoms and patient data.
Main Methods:
- Retrospective analysis of 349 patients who underwent chest CT before and after CAR T-cell therapy.
- Review of patient charts for demographic and clinical information.
- Independent review of CT scans by two cardiothoracic radiologists to identify new radiologic features.
Main Results:
- Pleural effusion was the most common CT manifestation (26.3% of patients).
- CT abnormalities were associated with increased likelihood of dyspnea and cough (p < 0.05).
Conclusions:
- New-onset symptoms in patients undergoing CAR T-cell therapy can signal radiologic abnormalities.
- Clinicians should maintain a high index of suspicion for pleural effusions in symptomatic patients post-CAR T-cell therapy.
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