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Giant Cell Myocarditis: Navigating Diagnosis and Management of a Mysterious Entity

Ibrahim Mortada1, Mohammed Mhanna1, Kathryn Eschbacher2

  • 1Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Health Care, Iowa City, Iowa.

The American Journal of Cardiology
|March 7, 2025
PubMed

Keywords:
cardiovascular pathologyendomyocardial biopsygiant cell myocarditisimmunosuppressive therapy

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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