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Mst1 knockout and Nrf2 activation alleviate diabetic cardiomyopathy pathogenesis through autophagy modulation in type
Jun Wang1, Lulu Wang2, Huixiang Zhang3
1Department of Pathophysiology, Qiqihar Medical College, Qiqihar 161006, China; Qiqihar Medical College, Key Laboratory of Drug Food Homologous Resources and Metabolic Disease Prevention and Treatment in Heilongjiang Province, Qiqihar 161006, China.
Abstract:
Diabetic cardiomyopathy (DCM) is a myocardial disorder resulting from glucose metabolism dysfunction, leading to structural and functional heart abnormalities independent of common cardiovascular conditions. This study explores the impact of Mammalian Sterile20-like Kinase 1 (Mst1) and Nuclear Factor E2-Related Factor 2 (Nrf2) pathways on autophagy in type 2 diabetic mice. By employing Mst1 knockout and Nrf2 activation, improvements in cardiac function reduced myocardial fibrosis, and decreased cardiomyocyte apoptosis was observed, with enhanced autophagy noted in Mst1 knockout mice further augmented by Nrf2 activation. The Mst1/Nrf2 pathway demonstrates a protective effect by regulating autophagy-related proteins, offering a potential therapeutic avenue for treating DCM in type 2 diabetes.
