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Updated: May 23, 2025
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
Three Decades of Photodynamic Therapy for Glioblastoma: A Comprehensive Scientometric Analysis
Jiheng Zhang1, Xiuwei Yan1, Xin Gao1
1Cancer Center, Department of Neurosurgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Background:
Photodynamic therapy (PDT) has emerged as a promising adjunctive treatment for glioblastoma (GBM), yet a comprehensive bibliometric analysis of this field is lacking. This study explores research trends, major contributors, and hotspots in PDT for GBM to provide an integrated overview of its development.
Methods:
Literature from 1993 to 2024 was retrieved from the Web of Science Core Collection. Bibliometric tools, including CiteSpace, analyzed publication trends, collaborations, and keyword co-occurrence to identify influential authors, institutions, and journals.
Results:
A total of 799 publications showed a growing research interest, peaking in 2022. The United States and China were leading contributors, with prominent institutions like the University of California System and Centre National de la Recherche Scientifique. Influential figures, such as Jiro Akimoto and Walter Stummer, advanced clinical applications and fluorescence-guided techniques. Early studies of PDT for GBM have focused on evaluating its efficacy and potential side effects, while recent research has transitioned toward innovative strategies like targeted drug delivery, nanotechnology, and combination therapies. However, the similarities between early and recent studies are in the search for safe and reliable photosensitizers. Keyword analysis highlighted "5-aminolevulinic acid", "in vitro", and "polyethylene glycol compounds" as key areas, while timeline analysis revealed shifts from foundational photosensitizer research to approaches addressing tumor heterogeneity and resistance.
Conclusions:
This study provides a systematic overview of PDT research for GBM, spotlighting breakthroughs and collaborative networks. The findings emphasize the importance of innovation and clinical translation to fully realize PDT's potential in GBM therapy.
