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Allostatic Load and Cardiovascular Disease: A Systematic Review
Elizabeth Evans1, Molly Jacobs2, David Fuller3
1Department of Speech, Language and Hearing Sciences, Communication Equity and Outcomes Laboratory, College of Public Health and Health Professions, University of Florida, Gainesville, Florida.
American Journal of Preventive Medicine
|March 7, 2025
Summary
Allostatic load, a measure of cumulative stress, is linked to cardiovascular disease incidence. More research is needed to understand its impact across different demographics and cardiovascular disease types.
Area of Science:
- Cardiovascular Health
- Stress Physiology
Background:
- Cardiovascular disease is a major cause of death.
- Allostatic load (cumulative stress) is linked to cardiovascular disease risk and health disparities.
- Variations in cardiovascular disease types and impairments may affect the allostatic load association.
Purpose of the Study:
- To systematically review the relationship between allostatic load and cardiovascular disease.
- To identify gaps in current knowledge regarding this association.
Main Methods:
- A systematic review of literature published in 2024.
- Searches conducted in PubMed, SCOPUS, and Web of Science.
- 22 studies included from an initial 233 articles.
Main Results:
- Allostatic load is associated with cardiovascular disease incidence.
- The relationship with cardiovascular disease mortality and other outcomes is less clear.
- Variations exist across cardiovascular disease types, race, and gender.
Conclusions:
- Significant knowledge gaps exist regarding allostatic load and cardiovascular disease.
- Further research should explore demographic differences, specific cardiovascular disease types, and outcomes like impairment.
- Standardized allostatic load measures and the impact of social determinants across the lifespan are needed.
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