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Kratom Cardiotoxicity: Reversible Brugada Pattern and QTc Prolongation
Andrew H F Miller1, Alex J Krotulski2, Sara E Walton2
1Atrium Health's Carolinas Medical Center, Department of Emergency Medicine, Division of Medical Toxicology, Charlotte, North Carolina, USA.
Abstract:
Kratom is derived from Mitragyna speciosa and contains active alkaloids that bind opioid, alpha-2 adrenergic, and 5-HT2A receptors. In vitro studies show kratom can inhibit myocardial potassium channels. We present a patient who developed a reversible Brugada pattern and QT prolongation after self-treating his attention-deficit/hyperactivity disorder with kratom.
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