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Kratom Cardiotoxicity: Reversible Brugada Pattern and QTc Prolongation
Andrew H F Miller1, Alex J Krotulski2, Sara E Walton2
1Atrium Health's Carolinas Medical Center, Department of Emergency Medicine, Division of Medical Toxicology, Charlotte, North Carolina, USA.
Kratom use in a patient with attention-deficit/hyperactivity disorder led to a reversible Brugada pattern and QT prolongation. This highlights potential cardiac risks associated with kratom, a herbal substance affecting multiple receptors.
Area of Science:
- Pharmacology
- Cardiology
- Herbal Medicine Research
Background:
- Kratom (Mitragyna speciosa) contains alkaloids interacting with opioid, adrenergic, and serotonergic receptors.
- In vitro studies suggest kratom may inhibit myocardial potassium channels.
Observation:
- A case study of a patient self-treating attention-deficit/hyperactivity disorder (ADHD) with kratom.
- The patient presented with cardiac abnormalities after kratom consumption.
Findings:
- The patient developed a reversible Brugada pattern.
- QT prolongation was observed in the patient's electrocardiogram.
- These cardiac events were linked to kratom use.
Implications:
- Kratom may pose risks for cardiac channelopathies, including Brugada pattern and QT prolongation.
- Healthcare providers should inquire about kratom use in patients with unexplained cardiac events.
- Further research is needed to elucidate the cardiovascular safety profile of kratom.
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