Overcoming Financial Barriers to Optimal Guideline-Directed Medical Therapy for Patients With Heart Failure
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Updated: May 23, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Ronald J Campbell1, Jennifer Kliner2, Heather Goetze1
1Department of Pharmacy, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
Insights
Financial barriers to heart failure with reduced ejection fraction (HFrEF) medications can be overcome. A medication optimization clinic helped a patient access all four pillars of guideline-directed medical therapy (GDMT) using patient assistance resources.
Area of Science:
- Cardiology
- Pharmacoeconomics
- Patient Care
Background:
- Optimizing guideline-directed medical therapy (GDMT) is crucial for managing heart failure with reduced ejection fraction (HFrEF).
- The high cost of novel HFrEF medications presents a significant financial challenge for many patients.
- Team-based care models can identify and leverage resources to mitigate these financial barriers.
Purpose of the Study:
- To illustrate how patient assistance resources can facilitate access to GDMT for HFrEF.
- To highlight the role of medication optimization clinics in overcoming cost-related treatment gaps.
Main Methods:
- A case study approach was used, focusing on a 79-year-old female patient with HFrEF.
- The patient's access to all four pillars of GDMT was evaluated.
- Utilization of patient assistance programs through a specialized clinic was central to the intervention.
Main Results:
- The patient successfully gained access to all four pillars of guideline-directed medical therapy.
- Patient assistance resources effectively addressed the financial barriers associated with prescribed medications.
- The medication optimization clinic played a key role in navigating and securing these resources.
Conclusions:
- Patient assistance resources are vital for ensuring equitable access to optimal HFrEF treatment.
- Medication optimization clinics are effective in facilitating team-based care to overcome financial obstacles in GDMT.
- This case demonstrates a successful strategy for improving HFrEF management by addressing medication affordability.
Abstract:
Optimizing guideline-directed medical therapy in patients with heart failure with reduced ejection fraction is paramount. The cost of the newer medications can be a financial barrier for many patients. There are numerous resources available for patients to help overcome financial barriers using team-based care. Here, we discuss a case of a 79-year-old woman with heart failure with reduced ejection fraction who gained access to all 4 pillars of guideline-directed medical therapy by utilizing patient assistance resources through a medication optimization clinic.
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