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Updated: May 23, 2025

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
Published on: May 12, 2023
A novel water-soluble dinuclear Pd(II) complex having 4,4'- bipyridine and diethylenetriamine ligands and its
Narjes Alisufi1,2, Effat Dehghanian3, Hassan Mansouri-Torshizi1
1Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran.
Abstract:
A novel dinuclear palladium(II) complex i.e., [{Pd(dien)}2(µ-4,4'-bpy)]Cl4, (dien = diethylenetriamine and bpy = bipyridine), has been synthesized and characterized by means of conductivity measurement, elemental analysis, FT-IR, 1D 1H NMR, 2D 1H NMR and 13C NMR. Binding characteristics of this complex to DNA and BSA was investigated by electronic absorption, fluorescence, electrophoresis, energy transfer, circular dichroism and cyclic voltammetry which revealed that van der Waals and hydrogen bonds are the main binding forces for the di-Pd(II) complex interaction with the mentioned biomacromolecules. The cytotoxicity assay of the di-Pd(II) complex has been performed on human acute lymphoblastic leukemia (MOLT-4) cell line. Finally, to identify DNA/BSA binding site for the metal complex, theoretical investigations were conducted utilizing molecular docking.
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