Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Bladder electromyograms and function in monkeys after atropine.

M D Craggs, J D Stephenson

British Journal of Urology

|June 1, 1985

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pelvic floor muscle training in spinal cord injury and its impact on neurogenic detrusor over-activity and incontinence.

Spinal cord·2015

Same author

Light touch and pin prick disparity in the International Standard for Neurological Classification of Spinal Cord Injury (ISNCSCI).

Spinal cord·2013

Same author

Action of 5 Hz repetitive transcranial magnetic stimulation on sensory, motor and autonomic function in human spinal cord injury.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2011

Same author

Development of quantitative and sensitive assessments of physiological and functional outcome during recovery from spinal cord injury: a clinical initiative.

Brain research bulletin·2010

Same author

Geochemistry of mineral licks at Loskop Dam Nature Reserve, Mpumalanga, South Africa.

Environmental geochemistry and health·2010

Same author

A controlled environment chamber (T).

British journal of pharmacology·2008

Same journal

Removal of ureteric calculus by the ureteric corkscrew in a case of calculous anuria.

British journal of urology·2010

Same journal

Obstructive anuria, probably due to calculus.

British journal of urology·2010

Same journal

The incidence of signs of renal injury following prolonged burial under debris in an unselected series of 764 airraid casualties admitted to hospital.

British journal of urology·2010

Same journal

Contribution to the etiology of acquired fibrosis of the bladder neck.

British journal of urology·2010

Same journal

True infective abacterial pyuria.

British journal of urology·2010

Same journal

A malignant right kidney removed at operation, together with a short length of the vena cava.

British journal of urology·2010

See all related articles

Conscious monkeys exhibit stable bladder voiding. Methyl-atropine significantly impacts voiding and electrical activity, indicating high sensitivity in both monkey and human bladders to atropine.

Area of Science:

Urology
Neuroscience
Pharmacology

Background:

Bladder function involves complex neural control.
Understanding voiding mechanisms is crucial for treating bladder dysfunction.
Animal models are essential for studying physiological processes like micturition.

Purpose of the Study:

To investigate the physiological mechanisms of bladder voiding in conscious monkeys.
To characterize the electrical activity associated with bladder filling and voiding.
To determine the effect of methyl-atropine on bladder activity and voiding reflexes.

Main Methods:

Sterile saline infusions into the bladder of conscious monkeys via chronic catheterization.
Electromyogram recordings from the bladder neck and dome during filling and voiding.

Related Experiment Videos

Administration of methyl-atropine to assess its pharmacological effects.

Sacral ventral root stimulation to evaluate reflex pathways.

Main Results:

Stable, repeatable voiding was achieved over extended periods.
Distinct electromyogram patterns were recorded from the bladder neck and dome during voiding, with neck activity preceding dome activity.
Low doses of methyl-atropine completely inhibited voiding and associated electromyograms.
Methyl-atropine also blocked evoked responses to sacral ventral root stimulation.

Conclusions:

Monkey bladders demonstrate high sensitivity to atropine, similar to human bladders.
The findings suggest a significant role for muscarinic receptors in regulating bladder voiding in primates.
Electromyography is a viable tool for studying primate bladder function and the effects of pharmacological agents.