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Long-Term Clinical Outcomes of the Transcatheter Aortic Valve System for Aortic Valve Stenosis

Zijia Wu1,2, Lulan Gao, Lei Chen1,2

  • 1Department of Cardiology, Yulin First People's Hospital, The Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi, China.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|March 7, 2025
PubMed

Insights

Transcatheter aortic valve replacement using a self-expanding system is safe and effective for Chinese patients with severe aortic stenosis. One-year follow-up showed low mortality and no major strokes, indicating promising clinical outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Severe aortic stenosis (AS) poses significant risks, especially for patients unsuitable for traditional surgery.
  • Transcatheter aortic valve replacement (TAVR) offers an alternative treatment modality.
  • Self-expanding transcatheter aortic valve systems are emerging technologies for TAVR.

Purpose of the Study:

  • To assess the clinical safety and efficacy of a self-expanding transcatheter aortic valve system.
  • To evaluate outcomes in Chinese patients with severe symptomatic aortic stenosis.
  • To determine the one-year mortality and complication rates post-TAVR.

Main Methods:

  • Retrospective analysis of 101 patients with severe symptomatic AS undergoing TAVR.
  • Inclusion of high-risk surgical patients or those with contraindications to conventional surgery.
  • Primary endpoint: one-year mortality or complications; secondary: stroke, coronary obstruction, valve type prognosis.

Main Results:

  • The cohort (average age 69.5 years, 39.6% female) had an average STS score of 3.5%.
  • One-year all-cause or cardiovascular mortality was 7.9%.
  • No major strokes or coronary artery obstructions were reported; bicuspid and tricuspid AS prognoses were comparable.

Conclusions:

  • The self-expanding transcatheter aortic valve system demonstrates safety and efficacy in Chinese patients with severe AS.
  • This TAVR system is a viable treatment option for this population.
  • Further large-scale, multicenter randomized controlled trials are warranted to confirm long-term benefits.
Abstract

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