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Updated: May 23, 2025

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A-kinase anchoring protein 1: an independent predictor of coronary artery disease

Wei Yan1, Yun-Lang Dai2, Jun-Xia Han3

  • 1Department of Geriatric Medicine, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

BMC Cardiovascular Disorders
|March 7, 2025
PubMed

Insights

Lower serum levels of A-kinase anchoring protein 1 (AKAP1) are linked to coronary artery disease (CAD). This finding suggests AKAP1 may serve as a potential biomarker for predicting CAD risk in patients.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Molecular Cardiology

Background:

  • Coronary artery disease (CAD) remains a leading global cause of mortality.
  • A-kinase anchoring protein 1 (AKAP1) is expressed in the heart and is believed to play a protective role.
  • Limited data exists on serum AKAP1 concentrations in CAD patients.

Purpose of the Study:

  • Quantify serum AKAP1 levels in patients with CAD.
  • Evaluate the predictive capability of serum AKAP1 for CAD.
  • Investigate the association between AKAP1 and CAD risk.

Main Methods:

  • Included 255 patients undergoing coronary angiography, categorized into CAD and non-CAD groups.
  • Performed comparative analysis of clinical data and serum AKAP1 levels.
  • Utilized multivariate logistic regression and ROC curve analysis to assess AKAP1's association with CAD.

Main Results:

  • Serum AKAP1 concentrations were significantly lower in the CAD group compared to the non-CAD group (P < 0.01).
  • Lower AKAP1 levels were independently associated with an increased risk of CAD (OR = 5.677, P = 0.005).
  • ROC analysis indicated a limited but present ability of AKAP1 to predict CAD (AUC = 0.649).

Conclusions:

  • Serum AKAP1 levels are inversely associated with CAD.
  • AKAP1 may serve as a potential predictive marker for coronary artery disease.
  • Further research is warranted to validate and elucidate these findings.
Abstract

Keywords:
A-kinase anchoring protein 1Cardioprotective rolesCoronary artery disease

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