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Related Concept Videos

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Related Experiment Video

Updated: May 23, 2025

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
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Rapid progression of right ventricular dysfunction: a case report.

Guoliang Li1, Changying Zhao2, Lingmin Wu3

  • 1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

BMC Cardiovascular Disorders
|March 7, 2025
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Summary
This summary is machine-generated.

Arrhythmogenic cardiomyopathy (ACM) can rapidly progress, suggesting a possible link to myocarditis. This inflammation may drive the transformation of heart tissue in some ACM patients.

Keywords:
Arrhythmogenic cardiomyopathyArrhythmogenic right ventricular cardiomyopathyMyocarditis

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Area of Science:

  • Cardiology
  • Genetics
  • Pathology

Background:

  • Arrhythmogenic cardiomyopathy (ACM) is a genetic heart muscle disease.
  • It involves myocyte loss and fibrofatty tissue replacement, leading to arrhythmias and impaired function.
  • The connection between ACM and myocarditis is increasingly recognized.

Purpose of the Study:

  • To investigate the potential role of myocarditis in rapid ACM progression.
  • To explore the inflammatory mechanisms underlying ACM pathogenesis.

Main Methods:

  • Case presentation of a 28-year-old female with advanced biventricular ACM.
  • Electrocardiogram (ECG) and echocardiogram for diagnosis and monitoring.
  • Histopathological examination of heart tissue post-transplantation.

Main Results:

  • The patient presented with edema and palpitations, showing advanced biventricular ACM on ECG.
  • Despite treatment, right ventricle (RV) function rapidly declined, requiring heart transplantation.
  • Postoperative analysis revealed significant lymphocytic infiltration, particularly in the RV.

Conclusions:

  • Rapid ACM progression may indicate concomitant myocarditis.
  • Myocarditis could be a factor in the fibrofatty transformation of heart tissue in ACM.
  • Inflammation may be integral to the natural history of some ACM cases.