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Association of Cardiologist Clinic Visits With Cardiovascular Primary Prevention Outcomes Among People With HIV From
Matthew S Durstenfeld1, C Larry Hill2, Robert M Clare2
1Division of Cardiology at Zuckerberg San Francisco General University of California San Francisco San Francisco CA USA.
Insights
Cardiology care did not improve blood pressure or lipid control in people with HIV (PWH) from underrepresented groups. Seeing a cardiologist was not associated with reduced cardiovascular events in this high-risk population.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- People with HIV (PWH) face higher cardiovascular disease (CVD) risk.
- Underrepresented racial and ethnic groups in the US South are disproportionately affected by HIV and CVD.
- The impact of cardiology care on CVD risk factors and events in this population is not well understood.
Purpose of the Study:
- To determine if cardiology care improves blood pressure and lipid control in PWH from underrepresented groups.
- To assess if cardiology care reduces major adverse cardiovascular events (MACE) in this population.
- To investigate the association between cardiology visits and CVD outcomes in high-risk PWH.
Main Methods:
- Retrospective cohort study of 3972 PWH from underrepresented groups receiving HIV care in the US South (2015-2020).
- Outcomes included blood pressure control (<140/90 mmHg), lipid control (LDL-C ≤100 mg/dL) over 2 years, and time to first MACE.
- Statistical analyses adjusted for sociodemographic factors, HIV status, and comorbidities.
Main Results:
- Only 6.9% of PWH had a cardiology clinic visit.
- Cardiology visits were not associated with improved blood pressure (aOR 0.78) or lipid control (aOR 2.25).
- A cardiology visit was associated with a higher risk of MACE and death over 5-year follow-up.
Conclusions:
- Cardiology care did not improve CVD risk factors or reduce MACE in PWH from underrepresented groups.
- Current cardiology care models may be insufficient for promoting cardiovascular health in this population.
- Further research is needed to understand the increased risk observed after cardiology visits.
Background:
People with HIV (PWH) have elevated cardiovascular risk. Underrepresented racial and ethnic groups in the southern United States are disproportionately affected, yet whether cardiology care for this at-risk group improves blood pressure and lipid control or prevents cardiovascular events is unknown.
Methods And Results:
We evaluated a cohort of PWH from underrepresented racial and ethnic groups who received HIV-related care at 4 centers in the southern United States during 2015 to 2018 with follow-up through 2020. Primary outcomes were blood pressure control (<140/90 mm Hg) and lipid control (low-density lipoprotein cholesterol ≤100 mg/dL) over 2 years and time to first major adverse cardiovascular event. Statistical analyses were adjusted for cohort/site and patient sociodemographic factors, HIV measures, and comorbidities. Among 3972 included PWH (median age, 47 years; 32.6% women) without diagnosed cardiovascular disease, 276 (6.9%) had a cardiology clinic visit. Cardiology visits were not associated with subsequent blood pressure control (adjusted odds ratio, 0.78 [95% CI, 0.49-1.24]; P=0.29) or lipid control (adjusted odds ratio, 2.25 [95% CI, 0.72-7.01]; P=0.16). Over 5-year follow-up, patients who had a cardiology visit had a higher risk of a major adverse cardiovascular event, death, and falsification end points, even after adjusting for measured risk factors.
Conclusions:
Among PWH from underrepresented racial and ethnic groups at elevated risk for cardiovascular disease, a cardiology clinic visit was not associated with risk factor improvement or reduced risk of a major adverse cardiovascular event. Our study suggests that seeing a cardiologist is not sufficient to promote cardiovascular health or prevent cardiovascular events among PWH, but with low confidence given the higher risk among those who had a cardiology visit.
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