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Prognostic Factors in Moderate-to-Large Pericardial Effusion Requiring Pericardiocentesis. A Single-Center

Sevil Gülaştı1, Berk Mutlu1, Cemil Zencir1

  • 1Adnan Menderes University School of Medicine, Department of Cardiology.

Kardiologiia
|March 8, 2025
PubMed

Insights

The neutrophil to lymphocyte ratio and hypoalbuminemia are key laboratory markers predicting mortality in patients with pericardial effusion. These findings aid in assessing prognosis for individuals requiring pericardiocentesis.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Clinical Pathology

Background:

  • Pericardial effusion is a common clinical finding.
  • Predictors of mortality in pericardial effusion patients are not well-established.
  • No prior studies have focused on laboratory parameters for mortality prediction in this cohort.

Purpose of the Study:

  • To identify prognostic factors for patients with moderate to large pericardial effusions.
  • To evaluate laboratory parameters as predictors of mortality.
  • To assess the utility of the neutrophil to lymphocyte ratio in predicting outcomes.

Main Methods:

  • Retrospective analysis of 156 patients undergoing pericardiocentesis (2013-2022).
  • Evaluation of laboratory values at admission, including albumin levels and neutrophil to lymphocyte ratio.
  • Receiver Operating Characteristic (ROC) curve analysis to determine predictive accuracy.

Main Results:

  • Hypoalbuminemia was significantly more frequent in non-survivors (p<0.001).
  • A lower median neutrophil to lymphocyte ratio was observed in survivors (p=0.005).
  • Neutrophil to lymphocyte ratio > 4.49 predicted mortality with 78.57% sensitivity and 51.75% specificity (AUC=0.622, p=0.013).

Conclusions:

  • Neutrophil to lymphocyte ratio and hypoalbuminemia are significant prognostic indicators.
  • Albumin levels in pericardial fluid and malignant pathology also influence prognosis.
  • These laboratory values at admission can aid in predicting outcomes for pericardial effusion patients.

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