Related Experiment Video

Updated: Jul 9, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
07:21

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

37.1K

[Transthyretin Amyloid Cardiomyopathy as the Cause of Aortic Stenosis]

M V Ezhikova1, S N Nasonova1, I V Zhirov1

  • 1Chazov Russian Cardiology Research and Production Complex, Moscow.

Kardiologiia
|March 8, 2025
PubMed

Insights

Diagnosing amyloid cardiomyopathy (ACM) is challenging due to varied symptoms like heart failure and valve issues. Differentiating amyloid-related aortic stenosis (AS) from degenerative AS is crucial, as amyloid causes 4-16% of AS in older adults.

Area of Science:

  • Cardiology
  • Cardiovascular Diseases
  • Amyloidosis

Background:

  • Amyloid cardiomyopathy (ACM) diagnosis presents significant challenges for clinicians.
  • Diverse clinical presentations, including heart failure with preserved ejection fraction and hypertrophic phenotypes, complicate ACM diagnosis.
  • Valvular complications, such as mitral/tricuspid insufficiency and aortic stenosis (AS), are common in ACM.

Purpose of the Study:

  • To highlight the diagnostic difficulties in amyloid cardiomyopathy (ACM).
  • To emphasize the importance of differentiating amyloid-origin aortic stenosis (AS) from degenerative AS.
  • To underscore the prevalence of amyloid as a cause of AS in older populations.

Main Methods:

  • Review of clinical manifestations of ACM.
  • Analysis of common valvular involvement in ACM, specifically aortic stenosis.
  • Literature review on the incidence of amyloidogenic AS in elderly patients.

Main Results:

  • ACM diagnosis is hindered by a wide spectrum of symptoms.
  • Aortic stenosis (AS) is a frequent valvular manifestation in ACM.
  • Amyloidosis accounts for 4-16% of AS cases in patients aged 65 and older.

Conclusions:

  • Accurate diagnosis of ACM requires awareness of its varied presentations.
  • Distinguishing amyloid AS from degenerative AS is critical for appropriate patient management.
  • Amyloidosis is an underrecognized cause of aortic stenosis in the elderly, necessitating specific diagnostic considerations.

More Related Videos

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

2.6K
Novel and Innovative Hybrid Technique for Type A Aortic Dissection06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

174

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...