Pathogenesis and treatment of perioperative hiccups: a narrative review

Hiccups affect 0.05% of general in-patients and up to 10% of patients with gastroesophageal reflux disease. Hiccups are typically self-limited. In certain cases, they can become persistent and intractable, suggesting a potentially more serious underlying pathological condition. Treatment of hiccups in the perioperative period is challenging as it is difficult to identify their causes, and the existing literature is mainly based on case studies. This review aims to comprehensively explore the aetiology, mechanisms and treatment of perioperative hiccups to provide new insights.

A systematic search was conducted in multiple databases such as PubMed, Embase, and Web of Science, for literature published within the past three decades. Search terms included 'Hiccups, Perioperative, Pathogenesis, Treatment, Lidocaine', etc. Inclusion criteria included original research articles, review papers and case reports that provided relevant information on the topic. Exclusion criteria were non-relevant studies, duplicates and articles with insufficient data.

Surgical, anaesthesia- and patient-related aetiological factors and mechanisms of perioperative hiccups were systematically analysed. Management strategies across different perioperative phases were summarized, highlighting the emerging evidence of lidocaine's therapeutic efficacy. Current understanding of perioperative hiccups is limited as it mainly depends on case reports and observational studies, lacking strong evidence from controlled clinical trials. Preoperative risk stratification, intraoperative dynamic assessment, and postoperative multimodal safety protocols are clinically essential.

Research on the pathogenesis and treatment of perioperative hiccups requires further enhancement. Large-scale prospective studies are needed to validate the proposed management strategies and treatment recommendations, which will be beneficial for improving the clinical management of this condition.