Related Experiment Video
Updated: May 23, 2025

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
Published on: May 22, 2018
Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics - 2024 update
Olujimi A Ajijola1, Tolga Aksu2, Rishi Arora3
1UCLA Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Abstract:
The intricate role of the autonomic nervous system (ANS) in regulating cardiac physiology has long been recognized. Aberrant function of the ANS is central to the pathophysiology of cardiovascular diseases. It stands to reason, therefore, that neuroscience-based cardiovascular therapeutics hold great promise in the treatment of cardiovascular diseases in humans. A decade after the inaugural edition, this White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology and pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.
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