Enhancing Osteogenesis through Bio-Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production

Fei Yu ¹, Xing Zhao ^2,3, Ting Jiang ⁴

⁰State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.

Advanced Science (weinheim, Baden-Wurttemberg, Germany) +

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March 8, 2025

View abstract on PubMed

Summary

Recombinant coral protein galaxin enhances bone regeneration by regulating mitochondrial metabolism in pre-osteoblasts. Galaxin-GelMA composites show promise for regenerative medicine applications.

Area Of Science

Biomaterials Science
Regenerative Medicine
Biochemistry

Background

Coral-derived scaffolds are used for bone regeneration but have limitations.
Osteoinduction, environmental impact, and calcification mechanisms of coral proteins require further study.

Purpose Of The Study

To investigate the role of recombinant coral protein galaxin in promoting osteogenesis.
To evaluate galaxin-GelMA composites for bone regeneration.

Main Methods

Investigated recombinant galaxin's interaction with ATP synthase β subunit in mouse pre-osteoblasts.
Assessed osteogenic potential of galaxin-GelMA composites in mouse mandibular defects.

Main Results

Recombinant galaxin regulates mitochondrial metabolism in pre-osteoblasts.
Galaxin promotes osteogenesis by interacting with ATP synthase.
Galaxin-GelMA composites demonstrate osteogenic potential in vivo.

Conclusions

Galaxin plays a key role in regulating mitochondrial function and osteogenesis.
Bio-inspired recombinant coral proteins offer potential for regenerative medicine.

Keywords:

bio‐inspired bone regeneration coral galaxin mitochondrial metabolism