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Related Concept Videos

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Tumor Progression

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Related Experiment Video

Updated: May 23, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

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A Novel 4-Tier Classification for Tumor Budding and the Importance of Tumor Invasive Patterns in the Prognosis of

Tejus V NagiReddy1, Samir Gupta1, Rupali Bavikar2

  • 1Dept. of Surgical Oncology, Dr. D. Y. Patil Medical College, Hospital & Research Center, Pune, India.

World Journal of Surgery
|March 8, 2025
PubMed
Summary

Tumor budding and invasive patterns are key indicators for colorectal cancer prognosis. These histopathological markers, tumor budding (TB) and tumor invasive patterns (TIPs), help predict nodal metastasis and improve accuracy.

Keywords:
colorectal cancernodal metastasistumor buddingtumor invasive pattern

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Area of Science:

  • Oncology
  • Pathology
  • Cancer Research

Background:

  • Colorectal carcinoma (CRC) presents a significant global health challenge.
  • The TNM staging system for CRC has limitations in fully capturing tumor behavior.
  • Tumor budding (TB) and tumor invasive patterns (TIPs) are emerging histopathological markers for CRC prognosis.

Purpose of the Study:

  • To assess the correlation between TB, TIP, and CRC prognosis.
  • To evaluate the prognostic value of TB and TIP in predicting nodal metastasis, lymphovascular invasion, and perineural invasion.
  • To explore the potential of TB and TIP as supplementary prognostic tools in CRC.

Main Methods:

  • An ambidirectional observational study included 60 biopsy-proven CRC patients.
  • Histopathological evaluation of TB and TIP was performed on H&E stained slides.
  • Statistical analysis, including multivariate analysis, was used to compare TB and TIP with histopathological parameters.

Main Results:

  • A significant association was found between TB and nodal metastasis (N) (p=0.018).
  • TIP showed a significant association with perineural invasion (PNI) (p=0.016).
  • Multivariate analysis identified TB as a strong predictor for N (OR=12.8, p<0.001).

Conclusions:

  • TB and TIP are valuable prognostic tools in CRC.
  • These markers offer insights into tumor behavior and metastasis potential.
  • Incorporating TB and TIP into routine histopathological evaluation could enhance prognostic accuracy for colorectal cancer.