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Updated: May 23, 2025

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

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Micro-RNAs targeting the estrogen receptor alpha involved in endocrine therapy resistance in breast cancer

J M Márquez-Mendoza1, N Baranda-Ávila2, M Lizano3

  • 1Programa de Doctorado en Ciencias Biomédicas, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|March 8, 2025
PubMed

Insights

MicroRNAs (miRNAs) targeting estrogen receptor alpha (ERα) mRNA are key players in endocrine therapy resistance (ETR) in breast cancer (BC). Understanding these miRNA mechanisms is crucial for overcoming ETR in BC patients.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Endocrine therapy resistance (ETR) is a significant challenge in breast cancer (BC) treatment.
  • Alterations in the tumor cell interactome, including non-coding RNAs (ncRNAs), contribute to ETR.
  • Micro-RNAs (miRNAs) are ncRNAs that regulate gene expression, impacting cancer development and treatment response.

Purpose of the Study:

  • To review the effects of miRNAs targeting estrogen receptor alpha (ERα) mRNA in breast cancer.
  • To elucidate the mechanisms by which these miRNAs contribute to endocrine therapy resistance (ETR).
  • To enhance the understanding of ETR in breast cancer through the study of miRNA involvement.

Main Methods:

  • Comprehensive literature review on miRNAs targeting ERα mRNA and ETR in BC.
  • In silico analysis to identify and validate miRNA-mRNA interactions.
  • Examination of the molecular mechanisms underlying miRNA-mediated ERα regulation.

Main Results:

  • Identified specific miRNAs that directly target ERα mRNA.
  • Elucidated diverse mechanisms through which these miRNAs influence ERα expression and ETR.
  • Demonstrated the significant role of miRNA-ERα interactions in the development of endocrine therapy resistance.

Conclusions:

  • miRNAs targeting ERα mRNA are critical modulators of endocrine therapy resistance in breast cancer.
  • Targeting these specific miRNAs presents a potential therapeutic strategy to overcome ETR.
  • Further research into miRNA-ERα interactions can lead to novel treatment approaches for breast cancer.
Keywords:
Breast cancerEndocrine therapy resistanceEstrogen receptor alphaNoncoding RNAsmicro-RNAs

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