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Prevalence of periodontitis in chronic heart failure patients and its relationship with NT-ProBNP: A cross-sectional

Sonika Sharma1, Deepti Mathur2, Sourabh Goswami2

  • 1School of Public Health, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Indian Heart Journal
|March 8, 2025
PubMed

Insights

Periodontal disease is common in chronic heart failure (CHF) patients. Severe periodontitis is linked to higher NT-proBNP levels, suggesting a cardiac impact in heart failure.

Area of Science:

  • Cardiology
  • Periodontology
  • Biomarkers

Background:

  • Periodontal disease is linked to adverse cardiovascular outcomes.
  • Few studies explore periodontitis in heart failure patients, especially from India.
  • This study investigates periodontitis prevalence and NT-proBNP correlation in CHF.

Purpose of the Study:

  • Assess periodontitis prevalence in chronic heart failure (CHF) patients.
  • Correlate periodontitis severity with NT-proBNP levels in CHF.
  • Investigate the potential cardiac impact of periodontal disease in heart failure.

Main Methods:

  • 154 stable CHF patients (ejection fraction <40%) were enrolled.
  • Cardiologic and dental evaluations were performed.
  • NT-proBNP levels and periodontal disease severity (using periodontal screening index) were assessed.

Main Results:

  • High prevalence of periodontitis: 31.2% gingivitis, 53.2% moderate, 15.5% severe.
  • Significant association between moderate/severe periodontitis and elevated NT-proBNP in patients <75 years (p<0.05).
  • Post hoc analysis showed significant differences between gingivitis and moderate/severe periodontitis.

Conclusions:

  • Moderate and severe periodontitis are highly prevalent in CHF patients.
  • Periodontitis severity is significantly associated with elevated NT-proBNP in CHF.
  • This relationship suggests a potential cardiac impact of periodontitis in heart failure.
Abstract

Keywords:
Cardiovascular diseasesChronic heart failureNT-proBNPPeriodontal disease

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