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How should antenatal counseling be given to parents in the fetal corpus callosum agenesis?

Hasan Süt1, Gülşah Aynaoğlu Yıldız2

  • 1Department of Obstetrics and Gynaecology, Ankara University Faculty of Medicine, Mamak, Ankara, RI, 06590, Turkey. hassann0@gmail.com.

BMC Pregnancy and Childbirth
|March 8, 2025
PubMed

Insights

Agenesis of the corpus callosum (CCA) is a fetal anomaly with varied outcomes. Non-isolated CCA often leads to poor pregnancy results, while isolated CCA shows mixed neurodevelopmental results, necessitating further research.

Area of Science:

  • Fetal Medicine
  • Neuroscience
  • Genetics

Background:

  • Corpus callosum agenesis (CCA) is a significant antenatal diagnosis.
  • Understanding antenatal and postnatal outcomes is crucial for management.
  • This study reviews CCA cases managed at a university clinic.

Purpose of the Study:

  • To analyze antenatal and postnatal outcomes of fetal corpus callosum agenesis.
  • To differentiate outcomes between isolated and non-isolated CCA.
  • To inform clinical management and genetic counseling.

Main Methods:

  • Retrospective and cross-sectional study of CCA cases (2012-2021).
  • Evaluation of genetic results, additional anomalies, termination, and mortality rates.
  • Postnatal neurodevelopmental assessment (motor, cognitive, behavioral, speech, personal-social, epilepsy).

Main Results:

  • 30 fetuses with CCA were analyzed; 62.5% were non-isolated and 74% were complete.
  • 43% of cases underwent termination, 10% had perinatal mortality, and 47% resulted in live births.
  • Among 14 children with postnatal follow-up, 35.7% had normal neurodevelopment (all isolated CCA), while 37.5% of isolated CCA cases had poor outcomes.

Conclusions:

  • Fetal CCA diagnosis requires further ultrasonographic and genetic evaluation.
  • Non-isolated CCA is associated with poor pregnancy outcomes, suggesting termination counseling.
  • Counseling for isolated CCA is complex, requiring more prospective research.
Abstract

Keywords:
Agenesis of corpus callosumCounselingNeurodevelopmentOutcomePrenatal diagnosis

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