Related Experiment Video

Updated: Jun 28, 2026

Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications

Xiaowen Xie1, Weici Liu1,2, Zhiyuan Yuan3

  • 1Department of Thoracic Surgery, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China.

Molecular Cancer
|March 8, 2025
PubMed

Insights

Epigenomic modifications regulate cancer metabolism and immune response. Targeting tumor immunometabolism via epigenomic changes offers promising new cancer therapies.

Area of Science:

  • Cancer Research
  • Immunology
  • Metabolism
  • Epigenetics

Background:

  • Tumors reprogram metabolism for growth and metastasis.
  • The tumor microenvironment (TME) suppresses anti-tumor immunity.
  • Immune cells in the TME adapt metabolically, altering immune function.

Purpose of the Study:

  • To review epigenomic modifications in cancer.
  • To summarize their roles in metabolic reprogramming and immunometabolism.
  • To explore therapeutic strategies targeting tumor immunometabolism and epigenomics.

Main Methods:

  • Systematic review of epigenomic modifications in tumors.
  • Analysis of their regulatory roles in tumor metabolism and the TME.
  • Delineation of classical and emerging research approaches.

Main Results:

  • Epigenomic modifications are crucial in cancer progression and treatment.
  • Metabolites and epigenomics interplay significantly in tumor immunometabolism.
  • Targeting tumor immunometabolism can modulate epigenomic modifications.

Conclusions:

  • Epigenomic regulation is central to tumor immunometabolism.
  • Combining metabolic therapies with immunotherapy shows promise for cancer treatment.
Keywords:
Cancer treatmentEpigenomicsImmunometabolismMetabolic reprogrammingScATAC-seqSpatial metabolomicsTumor

More Related Videos

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma13:18

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.