Ferroptosis in plant immunity
Nam-Soo Jwa1, Byung Kook Hwang2
1Division of Integrative Bioscience and Biotechnology, College of Life Sciences, Sejong University, Seoul 05006, Korea.
Plant Communications
|March 9, 2025
Summary
Plant immunity involves calcium, iron, and reactive oxygen species (ROS) signaling. Calcium influx triggers ferroptotic cell death, coordinating plant defense against pathogens.
Area of Science:
- Plant immunity
- Cellular signaling
- Biochemistry
Background:
- Plant cell death is crucial for immunity, involving calcium, iron, and reactive oxygen species (ROS).
- The resistosome, an NLR receptor complex, mediates hypersensitive response (HR) and effector-triggered immunity (ETI).
- Ferroptosis, an iron- and ROS-dependent cell death, is implicated in plant defense.
Purpose of the Study:
- To review the roles of calcium, iron, and ROS signaling in ferroptosis during plant immunity.
- To discuss the coordination of Ca2+ signaling with iron and ROS in plant immune responses.
- To highlight advances in understanding Ca2+-mediated ferroptotic cell death in plant defense.
Main Methods:
- Literature review of plant immunity and cell death mechanisms.
- Analysis of signaling pathways involving calcium, iron, and ROS.
- Examination of ferroptosis in the context of plant-pathogen interactions.
Main Results:
- Calcium influx through resistosomes mediates iron- and ROS-dependent ferroptotic cell death.
- Reduced glutathione reductase (GR) expression is linked to ferroptosis in ETI.
- Plant defense activator Acibenzolar-S-methyl (ASM) enhances ferroptosis.
Conclusions:
- Calcium signaling plays a key role in ferroptosis and plant immunity.
- Ferroptosis is a critical component of plant immune responses.
- Understanding Ca2+-mediated ferroptosis offers insights into effective plant defense strategies.
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