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A Retrospective Cohort Study Using Latent Growth Curve Models for Children With a Diagnosis of Asthma
Introduction:
This study examined lung function trajectory (FEV1 % predicted) in children with asthma and explored the influence of sex and asthma control on these trajectories.
Methods:
A retrospective cohort study used a latent growth curve model (LGCM) to analyze the FEV1 trajectory in children with asthma.
Results:
FEV1 followed a quadratic trajectory with significant individual variability. Males exhibited a significantly slower rate of FEV1 change compared to females (estimate = -1.029, p < .001) but a higher acceleration rate (estimate = 0.269, p < .001). Improved asthma control was associated with a significant enhancement in FEV1 over time (p < .01).
Discussion:
FEV1 growth followed a curvilinear trajectory, marked by gradual deceleration. Males had slower initial growth but greater acceleration. Asthma control significantly influenced lung function improvement.
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