Marine-derived compounds applied in osteoarthritis: function, challenges and future prospects.

Area of Science:

• Marine Biology
• Pharmacology
• Biochemistry

Background:

• Oceanic environments foster unique marine natural products with distinct structures and activities.
• Marine-derived compounds possess antioxidant, antibacterial, and anti-inflammatory properties beneficial for osteoarthritis treatment.

Purpose of the Study:

• To comprehensively review marine-derived compounds for osteoarthritis treatment.
• To summarize preclinical and clinical studies on marine compounds in osteoarthritis.
• To explore marine compounds in anti-osteoarthritis drug delivery systems.

Main Methods:

• Literature review of preclinical and clinical studies.
• Analysis of marine-derived compounds' pharmacological activities.
• Examination of drug delivery systems for marine compounds.

Main Results:

• Marine natural products exhibit significant potential in preventing and treating osteoarthritis.
• Current research is predominantly preclinical, with limited clinical validation.
• Safety, optimal dosage, and treatment duration for marine compounds require further investigation.

Conclusions:

• Marine-derived compounds offer promising therapeutic avenues for osteoarthritis.
• Further research, including clinical trials, is needed to establish efficacy and safety.
• Marine compounds could be developed into novel anti-osteoarthritis drugs and delivery systems.