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Updated: May 23, 2025

Visualizing Intracellular SNARE Trafficking by Fluorescence Lifetime Imaging Microscopy
Published on: December 29, 2017
The diverse functions of syntaxin 13 in endosome-mediated membrane fusion
Wenting Zhang1, Haolin Zhang1, Tianlong He1
1College of Chemistry and Life Science, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China.
Abstract:
SNARE is a crucial membrane fusion factor. It forms SNARE complex that play significant roles in regulating various biological functions. The SNARE protein family, including syntaxin13 (STX13), is highly conserved across various species, from yeast to humans. This review summarizes the molecular mechanisms by which STX13-associated SNARE complexes contribute to diverse endosome-mediated membrane fusions. Furthermore, multiple cofactors are essential for regulating the SNARE complexes-mediated membrane fusion. These include but are not limited to Rab GTPases and their effectors. The interaction of these factors with SNARE proteins constitutes a critical component driving vesicle fusion processes.
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