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Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

41
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
41
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

106
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
106

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Related Experiment Video

Updated: May 23, 2025

Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG
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Inhibitory control in Bipolar Disorder disclosed by theta band modulation.

Massimo Bertoli1, Filippo Zappasodi2, Pierpaolo Croce2

  • 1Department of Neuroscience, Imaging and Clinical Sciences, University 'G. D'Annunzio' of Chieti-Pescara, Chieti, Italy.

Journal of Affective Disorders
|March 9, 2025
PubMed
Summary

Bipolar disorder (BD) patients show impaired cognitive inhibition, even when euthymic. This impacts fronto-parietal network function, crucial for cognitive control, as evidenced by theta and beta frequency brain activity.

Keywords:
Bipolar DisorderCognitive inhibitionLogical quantifiersTheta frequency

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Cognitive inhibition is essential for cognitive control in both healthy individuals and those with psychiatric conditions.
  • Individuals with Bipolar Disorder (BD) exhibit persistent inhibitory deficits and impulsivity, even during euthymic periods.

Purpose of the Study:

  • To investigate the influence of inhibiting heuristics in favor of analytical strategies on processing quantified sentences.
  • To examine behavioral and electrophysiological (EEG) responses during a sentence-picture matching task involving logical quantifiers.

Main Methods:

  • A sentence-picture matching task was used to assess the processing of quantified sentences with universal and particular quantifiers.
  • Behavioral performance and electroencephalography (EEG) recordings were employed to measure brain oscillatory responses.

Main Results:

  • In healthy volunteers, universal quantifiers induced higher cognitive load and poorer performance compared to neutral controls.
  • EEG analysis revealed distinct theta frequency band modulations in medial frontal areas between healthy adults and BD patients, reflecting differences in cognitive control.

Conclusions:

  • Limited cognitive inhibition resources in BD patients, even during euthymia, affect fronto-parietal network functionality for cognitive control.
  • Frontal areas synchronized in theta and beta frequencies orchestrate cognitive control, with observed differences between healthy and BD groups.