Supramolecular oral delivery technologies for polypeptide-based drugs

Area of Science:

• Biomedical Engineering
• Materials Science
• Pharmaceutical Sciences

Background:

• Polypeptide-based drugs are increasingly developed for therapeutic applications.
• Oral supramolecular drug delivery systems (SDDSs) offer a promising platform for oral administration.
• SDDSs utilize noncovalent bonds for drug encapsulation and targeted release within the oral tract.

Purpose of the Study:

• To review the anatomical and environmental barriers of the oral tract for drug delivery.
• To summarize the application of polypeptide-based SDDSs across different oral sites (mouth, stomach, small intestine).
• To discuss strategies for overcoming delivery barriers and enhancing oral drug efficacy.

Main Methods:

• Anatomical analysis of the oral tract to identify delivery barriers.
• Review of existing literature on polypeptide-based SDDSs and their performance.
• Categorization of SDDS applications based on oral location and targeting.

Main Results:

• Identification of physical, microenvironmental, and systemic barriers affecting oral drug delivery.
• Demonstration of SDDSs' potential in delivering drugs to the mouth, stomach, and small intestine.
• Summary of successful drug delivery applications and strategies to mitigate challenges.

Conclusions:

• Oral SDDSs are effective for polypeptide drug delivery by addressing specific oral tract barriers.
• Biofriendly and stimuli-responsive SDDSs enhance drug encapsulation and targeted release.
• Further development of SDDSs is crucial for improving oral drug bioavailability and therapeutic outcomes.