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Updated: Jul 15, 2026

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
Published on: August 14, 2017
[Current status and progress of ALPPS]
1Department of Liver Oncology Surgery, Zhongshan Hospital, Fudan University, Institute of Liver Cancer Research of Fudan University, Shanghai 200032, China.
Abstract:
Surgical resection is the mainstay of curative treatment for long-term survival of patients with liver cancer. However, many patients are excluded for surgical resection due to insufficient future liver remnant(FLR). The two-stage hepatectomy (induction of FLR hypertrophy followed by tumor resection) is one of the main treatment strategies for insufficient FLR. The new associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is an important innovative procedure for inducing FLR hypertrophy, which has the advantages of rapid and significant induction of FLR hypertrophy as well as high tumor resection rate, but it was controversial in the early years due to high postoperative morbidity and mortality. After more than 10 years of development, ALPPS has made tremendous advance. Surgical safety of ALPPS has been significantly improved, and oncological benefits and other issues have been largely clarified. This article aims to introduce the current status and progress of ALPPS.
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