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Related Experiment Video

Updated: May 23, 2025

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

[Current status and progress of ALPPS].

J Zhou¹, Y F Peng¹

¹Department of Liver Oncology Surgery, Zhongshan Hospital, Fudan University, Institute of Liver Cancer Research of Fudan University, Shanghai 200032, China.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]

|March 9, 2025

Summary

This summary is machine-generated.

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) enables liver cancer patients with insufficient future liver remnant to undergo resection. This technique has evolved, improving safety and clarifying oncological benefits.

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Last Updated: May 23, 2025

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Area of Science:

Hepatobiliary Surgery
Surgical Oncology
Liver Regeneration

Background:

Surgical resection is key for liver cancer survival but often limited by insufficient future liver remnant (FLR).
Two-stage hepatectomy, including associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), is a strategy to increase FLR.
Early ALPPS faced controversy due to high morbidity and mortality.

Purpose of the Study:

To review the current status and advancements in ALPPS.
To highlight the evolution of ALPPS over the past decade.
To discuss the improved safety and clarified oncological outcomes of ALPPS.

Main Methods:

Review of literature on ALPPS development and outcomes.
Analysis of advancements in surgical techniques and patient management.
Evaluation of postoperative morbidity, mortality, and oncological benefits.

Main Results:

ALPPS demonstrates rapid and significant FLR hypertrophy.
High tumor resection rates are achievable with ALPPS.
Surgical safety and oncological benefits of ALPPS have been substantially improved over 10 years.

Conclusions:

ALPPS has evolved into a safer and more effective procedure for liver cancer patients with insufficient FLR.
The technique offers significant oncological benefits and has overcome initial controversies.
Continued research and refinement are advancing ALPPS in liver surgery.