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Related Concept Videos

Radical Autoxidation01:20

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The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
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  1. Home
  3. Research Domains
  5. Physical Sciences
  7. Condensed Matter Physics
  9. Surface Properties Of Condensed Matter
  11. Mechanisms Of Antioxidant Protection Of Low-density Lipoprotein Particles Against Free Radical Oxidation.
  1. Home
  3. Research Domains
  5. Physical Sciences
  7. Condensed Matter Physics
  9. Surface Properties Of Condensed Matter
  11. Mechanisms Of Antioxidant Protection Of Low-density Lipoprotein Particles Against Free Radical Oxidation.

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Mechanisms of Antioxidant Protection of Low-Density Lipoprotein Particles Against Free Radical Oxidation.

Vadim Z Lankin1, Konstantin B Shumaev2,3, Valeria A Medvedeva2

  • 1Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, 121552, Russia. lankin0309@mail.ru.

Biochemistry. Biokhimiia
|March 9, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Ubiquinone Q10 (CoQ10) supplementation reduces low-density lipoprotein (LDL) oxidation in patients with atherosclerosis. This study also explores the synergistic antioxidant effects of ubiquinol Q10 (CoQ10H2) and alpha-tocopherol (α-TOH) in LDL particles.

Keywords:
antioxidant bioregenerationantioxidantsfree radical oxidationlow-density lipoproteins

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Area of Science:

  • Biochemistry
  • Cardiovascular Research
  • Nutritional Science

Background:

  • Atherosclerosis involves low-density lipoprotein (LDL) oxidation, a key factor in disease progression.
  • Lipid peroxidation of LDL contributes to the development of atherosclerotic plaques.
  • Natural antioxidants play a crucial role in mitigating oxidative stress.

Purpose of the Study:

  • To investigate the effect of oral ubiquinone Q10 (CoQ10) on LDL oxidation in patients with atherosclerosis.
  • To examine the influence of ubiquinol Q10 (CoQ10H2) and alpha-tocopherol (α-TOH) on the oxidation kinetics of LDL particles in a model system.
  • To explore potential synergistic antioxidant mechanisms between CoQ10H2 and α-TOH within LDL particles.

Main Methods:

  • Administration of ubiquinone Q10 (CoQ10) to patients with atherosclerosis.
ubiquinol Q
α-tocopherol
  • In vitro assessment of Cu2+-induced free radical oxidation of LDL particles.
  • Kinetic analysis of antioxidant effects of ubiquinol Q10 (CoQ10H2) and α-tocopherol (α-TOH).

    • Main Results:

    • Oral CoQ10 administration significantly decreased LDL oxidation (lipid hydroperoxide content) in patients.
    • CoQ10H2 and α-TOH demonstrated antioxidant activity in the LDL oxidation model system.
    • Evidence suggests potential synergistic antioxidant interactions between CoQ10H2 and α-TOH.

    Conclusions:

    • CoQ10 is a vital natural antioxidant protecting LDL particles from oxidative damage in vivo.
    • CoQ10H2 and α-TOH exhibit antioxidant properties and may act synergistically in LDL particles.
    • Mechanisms of lipophilic antioxidant bioregeneration, including α-TOH regeneration, are proposed.