Associations between life's essential 8 and preserved ratio impaired spirometry

Area of Science:

• Pulmonary Medicine
• Cardiovascular Health
• Public Health

Background:

• Preserved ratio impaired spirometry (PRISm) is an under-researched lung function state linked to COPD and cardiovascular disease.
• Improving quality of life for PRISm subjects is a significant public health concern.

Purpose of the Study:

• To investigate the association between the American Heart Association's Life's Essential 8 (LE8) metrics and PRISm.
• To explore the relationship between LE8 components, behavioral factors, and PRISm prevalence.

Main Methods:

• Cross-sectional study using National Health and Nutrition Examination Survey (NHANES) data from 2,869 adults (2007-2012).
• Multivariable logistic regression and restricted cubic spline curves analyzed the association between LE8 scores and PRISm.
• Subgroup analyses examined correlations across different demographic groups.

Main Results:

• Higher LE8 scores demonstrated a significant inverse association with PRISm (OR=0.97; 95% CI, 0.96-0.98).
• A linear relationship was observed between LE8 scores and reduced PRISm odds.
• Health factors within LE8 showed a particularly strong correlation with PRISm, especially in high-income individuals.

Conclusions:

• Optimal adherence to LE8 metrics is associated with a lower prevalence of PRISm.
• Promoting LE8 adherence offers a potential strategy for PRISm prevention and management.
• Further research into LE8's role in respiratory and cardiovascular health is warranted.