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Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
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Vision Mamba and xLSTM-UNet for medical image segmentation.
Xin Zhong1, Gehao Lu2, Hao Li1
1School of Information Science and Engineering, Yunnan University, Yunnan, 650504, China.
Scientific Reports
|March 10, 2025
Summary
VMAXL-UNet, a new deep learning model, enhances medical image segmentation by integrating Structured State Space Models (SSM) and lightweight LSTMs (xLSTM). It effectively captures both local details and global context, outperforming existing methods for accurate lesion boundary detection.
Area of Science:
- Medical Imaging
- Artificial Intelligence
- Computer Vision
Background:
- Deep learning models like CNNs and Transformers are used for medical image segmentation.
- CNNs struggle with long-range dependencies due to limited receptive fields.
- Transformers capture global information but are computationally intensive for clinical use.
Purpose of the Study:
- Introduce VMAXL-UNet, a novel network combining SSM and xLSTM for efficient medical image segmentation.
- Address limitations of existing CNNs and Transformers in capturing both local and global features.
- Improve segmentation accuracy and robustness in complex medical imaging.
Main Methods:
- Developed VMAXL-UNet, integrating Visual State Space (VSS) and ViL modules in the encoder.
- VSS module uses SSM to capture long-range dependencies and extract features from distant regions.
- ViL module employs a gating mechanism for enhanced integration of local and global features.
Main Results:
- VMAXL-UNet demonstrated superior performance compared to traditional CNNs and Transformer-based models.
- The model excelled in capturing lesion boundaries and their distant correlations across multiple datasets (ISIC17, ISIC18, CVC-ClinicDB, Kvasir).
- Significant improvements in segmentation accuracy and robustness were observed.
Conclusions:
- VMAXL-UNet offers a promising approach for efficient and accurate medical image segmentation.
- The integration of SSM and xLSTM effectively balances local detail and global context.
- The model shows potential for practical application in clinical settings.

